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Department of Retrovirology: Research Projects

 

Ongoing Studies:

No.

Collaborators

Retro Protocol ID

Protocol title

Site/Study type

1

CDC-Thailand

N/A

HIV-1 Molecular Epidemiology in the Bangkok Men who have sex with Men (MSM) cohort study:CDC Protocol # 4614 sub study

Laboratory study

2

SEARCH

N/A

Peripheral Reservoir of HIV DNA in Monocytes Pivotal to Cognition in HIV

Laboratory study

3

THAI RED CROSS

N/A

Study of full-length and partial HIV genetic sequences in seroconverting blood donors collected during September 2007-March 2008

Laboratory study

4

MOPH/
TAVEG

RV144

A Phase III Trial of Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming With VaxGen gp120 B/E (AIDSVAX® B/E) Boosting in HIV-uninfected Thai Adults

Phase III

5

MOPH/TAVEG

RV152

Extended evaluation of the virologic, immunologic, and clinical course of volunteers who become HIV-1 infected during participation in a phase III vaccine trial of ALVAC-HIV and AIDSVAX® B/E

Natural history

6

MHRP
SIRIRAJ

RV158

Phase I trial MVA-CMDR among HIV-negative adults

Phase I

7

RTA

RV174

The Effect of the HLA B46+ Allele on the Natural History and Progression of HIV-1 Infections in Thailand

Laboratory study

8

MHRP

RV209

Immunological assessment of RV135, A phase I/II of Aventis  Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming with VaxGen 120 B/E (AIDSVAX B/E) Boosting in Thai-Seronegative  Adults, using recently validated immuno-monitoring assays

Laboratory study

9

THAI RED CROSS

RV212

A cross-sectional study to screen for and generate broadly neutralizing monoclonal antibodies from HIV infected individuals

Natural History

10

RTA

RV217d

HIV-1 Prevalence, Incidence, Cohort Retention, and Host Genetics and Viral Diversity in a Cohort in Thailand

High-risk Cohort
Acute HIV infection

11

MHRP

RV237

Development and Characterization of Reagents for Studies of HIV-1 Neutralization from Archived Cell and Plasma Samples

Laboratory study

12

SEARCH
PMK
Chulalongkorn

RV238

HIV-1 Specific Immune Responses in Thai Individuals with HIV Dementia

Laboratory Study

13

AFRIMS

RV243

Assessment of neutralizing antibody in participants from phase I/II Trials of ALVAC-HIV (vCP1521) priming with Chiron gp120 B/E, sanofi-pasteur oligomeric gp160, or AIDSVAX™ B/E gp120 B/E boosting against a newly developed, standardized panel of HIV-1 isolates

Laboratory study

14

THAI RED CROSS

RV254

Establish and charaterize an acute HIV infection cohort in a Thai high risk population

Therapeutic Cohort

15

RTA

RV262

Phase I Study of the Safety and Immunogenicity of PennVaxG DNA (Env (A, C, D) & consensus Gag) with IL-15 DNA Plasmid Adjuvant Administered by Intramuscular Biojector® 2000 Injection or by Intramuscular Electroporation using the CELLECTRA® Device Followed by MVA-CMDR (HIV-1 CM235 env/ CM240 gag/pol) Boost in Healthy, HIV Uninfected Adults

Phase 1b

16

AFRIMS

RV269-006

To determine the concentration, characterization, and neutralizing activity of mucosal and plasma antibodies from RV118/HSRRB Log #A-7856"

Laboratory study

17

MHRP

RV274

Specimen Collection Procedures for Clinical Laboratory Quality Management Practices

Laboratory study

18

AFRIMS

TBD

Characterization of humoral neutralizing activity in plasma of HIV individuals

Laboratory study

19

THAI RED CROSS

RV304

Characteristics of immune cells in gut mucosa of HIV negative and chronically HIV-infected Thais

Cohort study

20

MOPH/
TAVEG

RV305

Randomized, Double Blind Evaluation of Late Boost Strategies for HIV-uninfected Participants in the HIV Vaccine Efficacy Trial RV144: Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming with VaxGen gp120 B/E (AIDSVAX® B/E) Boosting in HIV-uninfected Thai Adults

Phase 2b
Follow on immunogenicity study 

21

TBD

RV306

Randomized, Double Blind Evaluation of Aventis Pasteur Live Recombinant ALVAC-HIV (vCP1521) Priming and Multiple Boosting Regimens with and without VaxGen gp120 B/E (AIDSVAX® B/E) in HIV-uninfected Thai Adults

Phase 2b 

22

THAI RED CROSS
KAROLINSKA INSTITUTE

RV310

RV254 patients on mega HAART getting MVA vaccine

Therapeutic vaccine
Phase 1

23

AFRIMS

 

Comparative Study of FcR-Mediated Antibody Effector Assays for HIV-1 (lab development in preparation for RV144 ADCC assays)

 Laboratory study

 

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